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Magnolia Bark Extract

Product Code:528-43-8
Main components:Magnolol
Formula:
Specifications:Magnolol 10-98%
Detection:HPLC

Product Description:
Product Name: Magnolia Bark Extract
Botanical name: Magnolia officnalis
Active ingredient: Magnolol, Honokiol, Tetrahhydromagnolol, Isomagnolol and so on.
Specification:
Extract Ratio 4:1 to 200:1
Straight powder
Honokiol 10-98% , Magnolol 10-98%
Honokiol and Magnolol 2%~98% HPLC
Appearance: Dark brown to White powder
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Active Ingredient: Magnolol
CAS No.: 528-43-8
Molecular Formula: C18H18O2
Molecular Mass: 266.33
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Active Ingredient: Honokiol
CAS No.: 35354-74-6
Molecular Formula: C18H18O2
Molecular Mass: 266.33

What is Magnolia Bark Extract produced in NutraMax?
Honokiol is a biphenolic compound present in the cones, bark, and leaves of Magnolia grandifloris that has been used in the traditional Japanese medicine Saiboku-to as an anxiolytic, antithrombotic, anti-depressant, anti-emetic, and anti-bacterial. While early research on the effective compounds in traditional remedies have simply used whole magnolia bark extracts, known as houpu magnolia, recent work has identified honokiol and its structural isomer magnolol as the active compounds in magnolia bark. In the late 1990s, honokiol saw a revival in western countries as a potent and highly tolerable anti-tumorigenic and neurotrophic compound.
Magnolol is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis). It is known to act on the GABA receptors in rats, as well as having antifungal properties.

Where will NutraMax ’s Magnolia Bark Extract used to?
Anti-tumorigenic activities :
Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia,
bladder, lung, prostate, oral squamous cell carcinoma andcolon cancer cell lines.
Honokiol inhibits phosphorylation of Akt, p44/42 mitogen-activated protein kinase (MAPK), and src.
Additionally, honokiolregulates the nuclear factor kappa B (NF-κB) activation pathway,
an upstream effector of vascular endothelial growth factor (VEGF), MCL1, and
cyclooxygenase 2 (COX-2), all significant pro-angiogenic and survival factors.
Neurotrophic activity :
Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons.
Additionally, honokiolincreases free cytoplasmic Ca2+ in rat cortical neurons.
Honokiol is a weak cannabinoid CB2 receptor ligand but the naturally occurring derivative 4-Omethylhonokiol
was shown to be a potent and selective cannabinoid CB2 receptor inverse agonist and to possess
antiosteoclastic effects.
Anti-thrombotic activity :
1) Honokiol inhibits platelet aggregation in rabbits in a dose-dependent manner, and protects cultured RAEC against oxidized low density lipoprotein injury.
2) Honokiol significantly increases the prostacyclin metabolite
6-keto-PGF1alpha, potentially the key factor in honokiol's anti-thrombotic activity.

Application of NutraMax ‘s Magnolia Bark Extract:
 (1). As the medicine of anti-inflammatory, antibacterial, antioxidant and anti-tumor drug, it is widely used in the fields of medicine and
health products;
(2). As a strong antioxidant, it is widely used in cosmetics industry.
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